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Meta-Analysis

Cross-dataset meta-analysis computes effect sizes and heterogeneity statistics across multiple datasets, enabling comparisons that no single dataset can answer.

Requires Academic verification.

Cross-Dataset Analysis

curl -X POST -H "Authorization: Bearer $TOKEN" \
  -H "Content-Type: application/json" \
  https://api.syndb.xyz/v1/meta-analysis \
  -d '{
    "table": "neurons",
    "metric": "mesh_volume",
    "grouping": "brain_structure",
    "dataset_ids": "uuid-1,uuid-2,uuid-3"
  }'

Parameters

FieldRequiredDescription
tableYesTarget table: neurons, synapses, dendrites, axons, pre_synaptic_terminals, dendritic_spines, vesicles, mitochondria
metricYesColumn to analyze (e.g., mesh_volume, mesh_surface_area, connection_score)
groupingYesGrouping dimension (e.g., species, brain_structure, cell_type, dataset)
dataset_idsYesComma-separated dataset UUIDs
scopeNo"local" (default) or "federation"
cluster_idsNoComma-separated federation cluster UUIDs; required when scope is federation

Atlas Comparison

Compare dataset metrics against reference atlases (pre-aggregated materialized views):

curl -H "Authorization: Bearer $TOKEN" \
  "https://api.syndb.xyz/v1/meta-analysis/atlas/compare?dataset_ids=uuid-1,uuid-2&grouping=species&metric=mesh_volume"

Federation Scope

To run meta-analysis across federated nodes:

{
  "table": "synapses",
  "metric": "connection_score",
  "grouping": "dataset",
  "scope": "federation",
  "dataset_ids": "uuid-1,uuid-2",
  "cluster_ids": "cluster-uuid-1,cluster-uuid-2"
}

The hub fans the aggregation out to each specified cluster and merges the results. See Cross-Cluster Queries.